NORMAN Substance Factsheets

Factsheets for: Acetaminophen

CHEMICAL IDENTITY

Norman SusDat IDNS00000231
NameAcetaminophen
CAS Registry Number103-90-2
SMILESCC(=O)NC1=CC=C(O)C=C1
InChIKeyRZVAJINKPMORJF-UHFFFAOYSA-N
Molecular structureAcetaminophen
Molecular formula
Monoisotopic mass [g/mol]151.063329
DSSTox Substance IDDTXSID2020006
PubChem CID1983

MAJOR USES

General information
Relevant media
Use categories - NORMAN
Product and Use Categories - DashBoard
Product or Use Categorization
consumer_use
drinking_water_contaminant:drug:detected
drug
drug:analgesic
drug:antipyretic
drug:dea_abuse_concern
drug:discontinued
drug:intermediate
drug:pediatric
drug_ACToRUseDB
food_contact:plastics
human_metabolite
industrial_manufacturing_ACToRUseDB
manufacturing:chemical
manufacturing:drug
personal_care
personal_care:health
pesticide
pesticide:active_ingredient
pesticide:pesticide_conventional
pesticide_ACToRUseDB
raw_material:drug
Chemical Functional Use - DashBoard
Reported functional use
SKINCONDITIONING skin_conditioner

PROPERTIES

LogKow experimental - DashBoard
LogKow predicted - DashBoard
Solubility experimental (mol/L) - DashBoard
Solubility predicted (mol/L) - DashBoard
Koc_min_experimental (L/kg) - DashBoard
Koc_max_experimental (L/kg) - DashBoard
Koc_min_predicted (L/kg) - DashBoard47.6
Koc_max_predicted (L/kg) - DashBoard47.6
Biodeg. Half-Life experimental (days) - DashBoard
Biodeg. Half-Life predicted (days) - DashBoard3.55
BCF experimental - DashBoard
BCF predicted - DashBoard6.65

ENVIRONMENTAL OCCURENCE (all data)

Occurrence data (NORMAN – all data)

Surface water
(relevant matrix)		 No. of Countries No. of Countries with Analysis > LOQ No. of Stations No. of Stations with Analysis > LOQ No. of Analysis Frequency of Quantification
Value 11 8 372 239 1445 49.00 %
Score1 n.a. 0.5 n.a. 0.5 n.a. 0.49

Occurrence data (NORMAN – recent data2)

Surface water
(relevant matrix)		 No. of Countries No. of Countries with Analysis > LOQ No. of Stations No. of Stations with Analysis > LOQ No. of Analysis Frequency of Quantification
Value 5 3 60 10 61 18.03 %
Score1 n.a. 0.2 n.a. 0.2 n.a. 0.18

LOQmin, Median, Max and MEC95 (NORMAN – all data1)

Matrix LOQmin
[µg/L]		 Median concentration [µg/L] Max concentration [µg/L] MEC95 [µg/L] (all data) MEC95 [µg/L] (recent data)

1 According to the NORMAN Prioritisation Methodology (Dulio & von der Ohe 2013)
2 Occurrence data from 2021 – 2026
MEC95 is the 95th percentile of the measured Maximum Environmental Concentrations at one site

ENVIRONMENTAL OCCURENCE (detailed information)

Per Country

CountryNo. of stationsNo. of analyses20012006200720082009201020112012201320142015201620172018201920202021
Antarctica418 8 7 3
Austria1243 7 34 2
Belgium35 5
Bulgaria1260 60
Croatia1238 14 24
Czech Republic1538 10 8 20
Denmark79 2 1 6
France237834548 81 2883 87 354 366 613 5389 6069 6991 5956 5756 3
Georgia39130 72 30 28
Germany3032556 873 1176 28 3 116 169 151 40
Greece46 1 5
Hungary2290 7 81 2
Ireland612 10 2
Italy44 1 3
Moldova, Republic Of721 21
Montenegro1339 39
Netherlands2523120 32 142 302 373 256 591 104 224 366 421 300 9
Norway24 2 1 1
Poland55 1 1 3
Portugal38629 144 207 207 69 2
Romania1645 3 20 21 1
Russian Federation612 2 10
Serbia1571 7 64
Slovakia1877 7 2 68
Slovenia1124 1 15 8
Spain91555 309 228 1 3 11 2 1
Sweden54150 16 76 2 4 6 8 14 2 22
Switzerland21187 24 135 12 16
Ukraine97350 120 50 33 146 1
United Kingdom2549 12 28 1 7 1

Per Matrix

MatrixTotal no. of analysesNo. of analyses above LoQMaxMedianUnitLowest PNECEQS
Surface water - Sea water 95 µg/l 46
Surface water - River water 33272 11954 130 0.0069 µg/l 46
Surface water - Lake water 86 19 0.09 0.043 µg/l 46
Surface water - Transitional water 35 15 0.36 0.17 µg/l 46
Surface water - Other 97 27 0.54 0.1 µg/l 46
Ground water 1023 198 0.481 0.007 µg/l 46
Waste water - Urban 343 280 4405.12 0.1376 µg/l 46
Waste water - Industrial 3 2 1.2888 0.0270314 µg/l 46
Waste water - Municipal 295 220 1905.52 20.074 µg/l 46
Waste water - Other 223 202 37399.6 25152.2 µg/l 46
Sediments - River water 12 µg/kg dry weight 182
Sediments - Transitional water 4 4 69 69 µg/kg dry weight 182
Sediments - Coastal water 30 µg/kg dry weight 182
Sediments - Territorial (marine) water 30 µg/kg dry weight 182
Sewage sludge - Municipal 3 3 73 11 µg/kg dry weight
Sewage sludge - Other 19 1 330 330 µg/kg dry weight
Biota - River water 29 1 3 3 µg/kg wet weight 306
Biota - Lake water 33 µg/kg wet weight 306
Biota - Transitional water 1 µg/kg wet weight 306
Biota - Coastal water 61 µg/kg wet weight 306
Biota - Territorial (marine) water 75 µg/kg wet weight 306
Biota - Terrestrial 33 µg/kg wet weight 306

(ECO)TOXICITY

Lowest PNEC fresh water (μg/L)46
Experimental / predicteddeterministic
Species n.r.
AF10
Endpoint
ReferencePNEC-ID-0347746
Lowest PNEC marine water (μg/L)13.4
Lowest PNEC sediment (µg/kg dw)182
Lowest PNEC biota (µg/kg ww)306

PBT/vPvB & PMT/vPvM (NORMAN)

Under construction

CMR & ED (NORMAN)

Under construction

POTENTIAL RISK OF EXCEEDANCE OF LOWEST PNEC

Summary: Risk of Exceedance of the Lowest PNEC
 ValueScore1
Frequency of Exceedance0.00 %
Extent of Exceedance0.00

1 According to the NORMAN Prioritisation Methodology (Dulio & von der Ohe 2013)

CONCLUSIONS AND RECOMMENDATIONS

Under construction

BIBLIOGRAPHY, SOURCES AND SUPPORTIVE INFORMATION

Dulio V. and Von der Ohe P. (2013) NORMAN Prioritisation framework for emerging substances. NORMAN Association, Verneuil en Halatte, France, 70 pages.

NORMAN organises the development and maintenance of various web-based databases for the collection & evaluation of data / information on emerging substances in the environment

NORMAN Database System

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